Poster Presentation NZAPS and ANZSOPS Joint Scientific Meeting

Periorbital desmoplastic cutaneous squamous cell carcinoma (648)

Verona E Botha 1 , Kent Chow 1 , Paul JM Salmon 2 , Rami El-Khayat 2 , Ye Chan 3 , Dinesh Selva 3 , Stephen GJ Ng 1
  1. Department of Ophthalmology, Waikato Hospital, Hamilton, New Zealand
  2. Skin Centre, Tauranga, New Zealand
  3. South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, SA, Australia


Desmoplasia is the formation of a densely collagenous stroma around a neoplasm. It occurs in a variety of malignancies including squamous cell carcinoma (SCC). While desmoplasia is uncommonly found in cutaneous SCC, it has been identified as an independent risk factor for local recurrence. We report a case series of desmoplastic SCC of the periorbital region.



Retrospective chart review.



Seven cases were identified: four of them male, median age 68. The mean follow-up was 48 months. In all cases the resulting defect after tumour excision was significantly larger than the estimated tumour size at presentation. 2 cases (29%) had aggressive local recurrence: one case required extensive salvage surgery including orbital exenteration and parotidectomy; the other case required repeat wide excision and adjuvant radiotherapy.



Desmoplastic SCC is a rare but highly aggressive variant that is infiltrative and locally aggressive. In the periocular region, it is potentially sight & life-threatening if it is not recognised & treated before orbital invasion occurs.